Detail Phylogenetic analysis of the emerge of main hepatitis C virus subtypes in Sao Paulo, Brazil (from The Brazilian Journal of Infectious Diseases, 2015, 19 (5), 473-478) Bibliografi Author: Nishiya, Anna Shoko ; Almeida-Neto, Cesar de ; Romano, Camila Malta ; Alencar, Cecilia Salete ; Ferreira, Sezete Cleusa ; Di-Lorenzo-Oliveira, Claudia ; Levi, Jose Eduardo ; Salles, Nanci Alves ; Mendrone-Junior, Alfredo ; Sabino, Ester Cerdeira Topik: Growth rate; HCV; Phylogenetic analysis; Subtypes; Hepatitis - Cadangan Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2015     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 1-s2.0-S1413867015001336-main.pdf (1.03MB; 0 download) Abstract tBackground: It is recognized that hepatitis C virus subtypes (1a, 1b, 2a, 2b, 2c and 3a) origi-nated in Africa and Asia and spread worldwide exponentially during the Second World War(1940) through the transfusion of contaminated blood products, invasive medical and dentalprocedures, and intravenous drug use. The entry of hepatitis C virus subtypes into differentregions occurred at distinct times, presenting exponential growth rates of larger or smallerspread. Our study estimated the growth and spread of the most prevalent subtypes currentlycirculating in São Paulo.Methods: A total of 465 non-structural region 5B sequences of hepatitis C virus covering a 14-year time-span were used to reconstruct the population history and estimate the populationdynamics and Time to Most Recent Common Ancestor of genotypes using the BayesianMarkov Chain Monte Carlo approach implemented in BEAST (Bayesian evolutionary analysisby sampling tree software/program).Results: Evolutionary analysis demonstrated that the different hepatitis C virus subtypes haddistinct growth patterns. The introduction of hepatitis C virus-1a and -3a were estimatedto be circa 1979 and 1967, respectively, whereas hepatitis C virus-1b appears to have a moreancient entry, circa 1923. Hepatitis C virus-1b phylogenies suggest that different lineagescirculate in São Paulo, and four well-supported groups (i.e., G1, G2, G3 and G4) were identified.Hepatitis C virus-1a presented the highest growth rate (r = 0.4), but its spread became lessmarked after the 2000s. Hepatitis C virus-3a grew exponentially until the 1990s and had an intermediate growth rate (r = 0.32). An evident exponential growth (r = 0.26) was found for hepatitis C virus-1b between 1980 and the mid-1990s. Conclusions: After an initial period of exponential growth, the expansion of the three main subtypes began to decrease. Hepatitis C virus-1b presented inflated genetic diversity, and its transmission may have been sustained by different generations and transmission routes other than blood transfusion. Hepatitis C virus-1a and -3a showed no group stratification, most likely due to their recent entry. [hepatitis - cadangan] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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