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Detail
BukuHCV regulation of host defense
Bibliografi
Author: Carney, D. Spencer ; Jr., Michael Gale
Topik: HCV; Hepatitis - Buku HCV
Bahasa: (EN )    
Tahun Terbit: 0    
Jenis: Books - Textbook
Fulltext: Bookshelf_NBK1618.pdf (753.25KB; 0 download)
Abstract
Mammalian cells respond to virus challenge by initiating a "host response" characterized by interferon a/ß (IFN) production and a cellular antiviral state. The host response is our first line of immune defense against viral pathogens and it imposes several barriers that hepatitis C virus (HCV) must overcome to replicate and persist. HCV evades the host response through a complex combination of virus-host interactions that disrupt intracellular signaling pathways and attenuate the antiviral actions of IFN. Regulation of the host response breaks a link between innate and adaptive immunity and provides a foundation for HCV replication and spread.

[hepatitis - buku HCV: chapter 13]
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