Detail Recent progress in adjuvant discovery for peptide-based subunit vaccines (from Human Vaccines & Immunotherapeutics 2014, 20 (3), 778-796) Bibliografi Author: Azmi, Fazren ; Fuaad, Abdullah Al Hadi Ahmad ; Skwarczynski, Mariusz ; Toth, Istvan Topik: Peptide vaccine; Adjuvant; Dendritic cell; Toll-like receptor; Vaccine delivery; Seminar - Thesis lit Bahasa: (EN )     Penerbit: Landes Bioscience     Tempat Terbit: Austin    Tahun Terbit: 2014     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: hvi-10-778.pdf (2.69MB; 0 download) Abstract Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are safe, easy to produce and well defined. However, peptide antigens produce a relatively weak immune response, and thus require the use of immunostimulants (adjuvants) for optimal efficacy. Developing a safe and effective adjuvant remains a challenge for peptide-based vaccine design. Recent advances in immunology have allowed researchers to have a better understanding of the immunological implication of related diseases, which facilitates more rational design of adjuvant systems. Understanding the molecular structure of the adjuvants allows the establishment of their structure-activity relationships which is useful for the development of next-generation adjuvants. This review summarizes the current state of adjuvants development in the field of synthetic peptide-based vaccines. The structural, chemical and biological properties of adjuvants associated with their immunomodulatory effects are discussed. [seminar - thesis lit] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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