Detail In silico predicted mycobacterial epitope elicits in vitro T-cell responses (from Molecular Immunology 2014, 61, 16-22) Bibliografi Author: Khan, Md Kawsar ; Zaman, Shabnam ; Chakraborty, Sajib ; Chakravorty, Rajib ; Alam, Mohammad Murshid ; Bhuiyan, Taufiqur Rahman ; Rahman, Muhammad Jubayer ; Fernandez, Carmen ; Qadri, Firdausi ; Seraj, Zeba I. Topik: Tuberculosis; Immuno informatics; Epitope vaccine; Ag85B; Seminar - Thesis lit Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2014     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: contoh1.pdf (1.88MB; 0 download) Abstract Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce the necessaryimmune response, thus providing a rational alternative to conventional design approaches. Using a rangeof immunoinformatics tools, we identified a novel, contiguous 28 amino acid multi-epitope cluster withinthe highly conserved secretory protein Ag85B of Mycobacterium tuberculosis, the causative agent of TB.This cluster, named Ep85B, is composed of epitopes which bind to three HLA Class I and 15 Class IImolecules, and harbors the potential to generate 99% population coverage in TB-endemic regions. Weexperimentally evaluated the capacity of Ep85B to elicit T-cell immune responses using whole bloodcells and, as predicted, observed significant increases in populations of both CD4+ and memory CD4+CD45RO+ T-cells. Our results demonstrate the practical utility of an epitope-based design methodology– a strategy that, following further evaluation, may serve as an additional tool for the development ofnovel vaccine candidates against TB and other diseases. [Seminar - Thesis lit] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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