Detail HLA Class II Alleles and Chronic Hepatitis C Virus Infection (from Scandinavian Journal of Immunology 2011, 74, 282-287) Bibliografi Author: Cangussu, L. O. F. ; Teixeira, R. ; Campos, E. F. ; Rampim, G. F. ; Mingoti, S. A. ; Martisn-Filho, O. A. ; Gerbase-DeLima, M. Topik: Hepatitis C; HCV; HLA - Class II; Seminar - Thesis lit Bahasa: (EN )     Penerbit: Blackwell Publishing Ltd.     Tahun Terbit: 2011     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Cangussu_et_al-2011-Scandinavian_Journal_of_Immunology.pdf (81.73KB; 0 download) Abstract The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis / cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis / cirrhosis (METAVIR scores F3–F4) was present in 49 patients. HLADRB1 specificities and DRB1*11 and DQB1* alleles were determined by PCR-SSP, and their frequencies were compared between patients and a control group of 103 healthy white Brazilian individuals. The results confirmed previous reports of the association of DRB1*11 and DQB1*03 with protection from chronic HCV infection, but did not confirm their association with protection from severe fibrosis / cirrhosis. Furthermore, the results suggested that the polymorphic sites on HLA molecules responsible for protection from chronic HCV infection are encoded not only by the DRB1*1101 and DQB1*0301, as suggested in the literature, but also by other DRB1*11 and DQB1*03 alleles. Thus, we hypothesized that the common polymorphic residues shared by different DRB1*11 and / or DQB1*03 alleles might be responsible for selection of viral epitopes for presentation to CD4+ T cells, leading to an efficient immune response against the virus. [seminar - thesis lit] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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