Detail Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses (from Clinical and Developmental Immunology 2013) Bibliografi Author: Molero-Abraham, Magdalena ; Lafuente, Esther M. ; Flower, Darren R. ; Reche, Pedro A. Topik: Hepatitis C; HCV; Seminar - Thesis lit Bahasa: (EN )     Penerbit: Hindawi Publishing Corporation     Tempat Terbit: New York    Tahun Terbit: 2013     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 601943.pdf (2.66MB; 0 download) Abstract The hepatitis C virus (HCV) is able to persist as a chronic infection, which can lead to cirrhosis and liver cancer.There is evidence that clearance ofHCVis linked to strong responses byCD8 cytotoxic T lymphocytes (CTLs), suggesting that elicitingCTL responses againstHCV through an epitope-based vaccine could prove an effective means of immunization.However,HCV genomic plasticity as well as the polymorphisms of HLA I molecules restricting CD8 T-cell responses challenges the selection of epitopes for a widely protective vaccine. Here, we devised an approach to overcome these limitations. From available databases, we first collected a set of 245 HCV-specific CD8 T-cell epitopes, all known to be targeted in the course of a natural infection in humans. After a sequence variability analysis, we next identified 17 highly invariant epitopes. Subsequently, we predicted the epitope HLA I binding profiles that determine their potential presentation and recognition. Finally, using the relevant HLA I-genetic frequencies, we identified various epitope subsets encompassing 6 conserved HCV-specific CTL epitopes each predicted to elicit an effective T-cell response in any individual regardless of their HLA I background.We implemented this epitope selection approach for free public use at the EPISOPT web server. [seminar - thesis lit] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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