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BukuProspects for Prophylactic and Therapeutic Vaccines Against Hepatitis C Virus (from Clinical Infectious Diseases 2012, 55 (1), 25-32)
Bibliografi
Author: Feinstone, Stephen M. ; Hu, Dale J. ; Major, Marian E.
Topik: HCV; Prophylactic; Therapeutic vaccines; Semiar - thesis lit
Bahasa: (EN )    
Penerbit: Oxford University Press on behalf of the Infectious Diseases Society of America     Tahun Terbit: 2012    
Jenis: Article - diterbitkan di jurnal ilmiah internasional
Fulltext: cis362.pdf (154.98KB; 0 download)
Abstract
Natural cross-protective immunity is induced after spontaneous clearance of primary hepatitis C virus (HCV)
infection. Although this suggests that effective prophylactic vaccines against HCV are possible, there are still
several areas that require further study. Current data indicate that, at best, vaccine-induced immunity may
not completely prevent HCV infection but rather prevent persistence of the virus. However, this may be an
acceptable goal, because chronic persistence of the virus is the main cause of pathogenesis and the development
of serious liver conditions. Therapeutic vaccine development is also highly challenging; however, strategies
have been pursued in combination with current or new treatments in an effort to reduce the costs and
adverse effects associated with antiviral therapy. This review summarizes the current state of HCV vaccines
and the challenges faced for future development and clinical trial design.

[seminar - thesis lit]
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