Detail Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection (from Nature Medicine 2013, 19 (12), 1638-1644) Bibliografi Author: Park, Su-Hyung ; Veerapu, Naga Suresh ; Shin, Eui-Cheol ; Biancotto, Angelique ; McCoy, J. Philip ; Capone, Stefania ; Folgori, Antonella ; Rehermann, Barbara Topik: Hepatitis C; HCV; D seminar Bahasa: (EN )     Penerbit: Nature America, Inc.     Tahun Terbit: 2013     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: park2013.pdf (1,022.72KB; 0 download) Abstract Hepatitis C virus (HCV) is endemic in many countries due to its high propensity for establishing persistence1. The presence of HCV-specific T cells in subjects repeatedly exposed to HCV who test negative for HCV RNA and antibodies and who do not have any history of HCV infection has been interpreted as T cell–mediated protection2–5. Here, we show in nonhuman primates that repeated exposure to human plasma with trace amounts of HCV induced HCV-specific T cells without seroconversion and systemic viremia but did not protect upon subsequent HCV challenge. Rather, HCV-specific recall and de novo T cell responses, as well as intrahepatic T cell recruitment and interferon-g (IFN-g) production, were suppressed upon HCV challenge, concomitant with quantitative and qualitative changes in regulatory T cells (Treg cells) that occurred after subinfectious HCV exposure and increased after HCV challenge. In vitro Treg cell depletion restored HCV-specific T cell responses. Thus, T cells primed by trace amounts of HCV do not generate effective recall responses upon subsequent HCV infection. Subinfectious HCV exposure predisposes to Treg cell expansion, which suppresses effector T cells during subsequent infection. Strategies to reverse this exposure-induced immune suppression should be examined to aid in the development of T cell-based vaccines against HCV and other endemic pathogens. [d seminar] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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