Detail Antibody Reactive to a Hepatitis C Virus (HCV)-Derived Peptide Capable of Inducing HLA-A2 Restricted Cytotoxic T Lymphocytes is Detectable in a Makority of HCV-Infected Individuals withour HLA-A2 Restriction (from Microbiology and Immunology 2004, 48 (7), 507-517) Bibliografi Author: Takao, Yukari ; Yamada, Akira ; Yutani, Shigeru ; Sata, Michio ; Itoh, Kyogo Topik: HCV; Peptide; Cytotoxic T-lymphocytes; Antibody; Validation ref - 6 Bahasa: (EN )     Tahun Terbit: 2004     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Takao_et_al-2004-Microbiology_and_Immunology.pdf (230.17KB; 0 download) Abstract Hepatitis C virus (HCV) is a single-strand RNA virus. Approximately 170 million people around the world are persistently infected and are at risk of liver cirrhosis or cancer. There is an urgent need to develop both therapeutic and diagnostic modalities of HCV. One approach to achieve these goals would be to determine highly immunodominant HCV peptides which are recognized by both cellular and humoral immunities. This study reports one such peptide, HCV-core protein at positions 35–44, having HLA-A2 binding motifs. IgG specific to this CTL-epitope peptide is consistently detectable in a majority of the patients with HCV infection regardless of the different HLA types, different disease conditions, and different HCV-genotypes tested. The sequence LPRR at positions 37–40 is considered to be the fine epitope recognized by the IgG. These results may provide new insights for the development of both therapeutic and diagnostic modalities of HCV at lower costs. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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