Detail Lack of Optimal T-Cell Reactivity Against the Hepatitis C Virus is Associated with the Development of Fibrosis/Cirrhosis During Chronic Hepatitis (from Human Immunology 2003, 64, 224-230) Bibliografi Author: Sreenarasimhaiah, Jayaprakash ; Jaramillo, Andres ; Crippin, Jeffrey ; Lisker-Melman, Mauricio ; Chapman, William C. ; Mohanakumar, T. Topik: CD4 T cells; CD8 T cells; Chronic infection; Cirrhosis; Hepatitis C virus; Validation ref - 6 Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2003     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: sreenarasimhaiah2003.pdf (129.67KB; 0 download) Abstract Chronic hepatitis C virus (HCV) infection develops in 85% of exposed individuals and 20% develop cirrhosis. However, the pathogenesis of this process is not well-understood. The objective of this study was to determine whether HCV-reactive T cells play a role in the process of development of cirrhosis during chronic HCV infection. We analyzed 21 human leukocyte antigen (HLA)-A2 patients with chronic HCV infection (9 with histology of inflammation and 12 with histology of fibrosis/cirrhosis). The frequency of CD8 T cells reactive to 12 HCV-derived epitopes was determined by an interferon- enzyme-linked immunospot (ELISPOT) assay. The frequency of CD4 Th1 and Th2 cells reactive to the HCV core antigen was determined by interferon- and interleukin-5 ELISPOT assays, respectively. Patients with histology of inflammation showed a significantly higher CD8 T-cell response to five HCV-derived epitopes (YLLPRRGPRL [core], CINGVCWTV [NS3], LLCPAGHAV [NS3], ILAGYGAGV [NS4B], and GLQDCTMLV [NS5B]) as compared with patients with histology of fibrosis/cirrhosis. Also, patients with histology of inflammation showed a significantly higher CD4 Th1 response to the HCV core antigen as compared to patients with histology of fibrosis/cirrhosis. These results indicate that a lack of an optimal T-cell response to HCV is associated with the development of cirrhosis during chronic HCV infection. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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