Detail Intrahepatic CD8+ T-Cell Failure During Chronic Hepatitis C Virus Infection (from Hepatology 2005, 42 (4), 828-837) Bibliografi Author: Spangenberg, Hans Christian ; Viazov, Sergei ; Kersting, Nadine ; Neumann-Haefelin, Christoph ; McKinney, Denise ; Roggendorf, Michael ; Weizsacker, Fritz von ; Blum, Hubert E. ; Thimme, Robert Topik: HCV; Hepatitis C; Validation ref - 6 Bahasa: (EN )     Penerbit: American Association for the Study of Liver Disease     Tahun Terbit: 2005     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Spangenberg_et_al-2005-Hepatology.pdf (276.04KB; 0 download) Abstract The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)-specific CD8 T cells to control the virus during persistent infection have not been fully defined. We therefore studied the CD8 T-cell response in 27 HLA-A2–positive patients using four previously well-defined HLA-A2–restricted HCV epitopes. The corresponding HCV sequences were determined in several patients and compared with the intrahepatic HCV-specific CD8 T-cell response. The results of the study indicate: (1) intrahepatic HCV-specific CD8 T cells are present in the majority of patients with chronic HCV infection and overlap significantly with the response present in the peripheral blood. (2) A large fraction of intrahepatic HCV-specific CD8 T cells are impaired in their ability to secrete interferon  (IFN-). This dysfunction is specific for HCV-specific CD8 T cells, since intrahepatic Flu-specific CD8 T cells readily secrete this cytokine. (3) T-cell selection of epitope variants may have occurred in some patients. However, it is not an inevitable consequence of a functional virus-specific CD8 T-cell response, since several patients with IFN-–producing CD8 T-cell responses harbored HCV sequences identical or cross-reactive with the prototype sequence. (4) The failure of intrahepatic virus–specific CD8 T cells to sufficiently control the virus occurs despite the presence of virus-specific CD4 T cells at the site of disease. In conclusion, different mechanisms contribute to the failure of intrahepatic CD8 T cells to eliminate HCV infection, despite their persistence and accumulation in the liver. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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