Detail Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients (from Journal of Gastroenterol 2006, 41, 758-764) Bibliografi Author: Shiina, Masaaki ; Kobayashi, Koju ; Kobayashi, Tomoo ; Kondo, Yasuteru ; Ueno, Yoshiyuki ; Shimosegawa, Tooru Topik: MHC-tetramer; Dendritic cells; Hepatitis C virus; Cytotoxic T lymphocytes; Anti-viral therapy; Validation ref - 6 Bahasa: (EN )     Tahun Terbit: 2006     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: art_3A10.1007_2Fs00535-006-1843-9.pdf (372.82KB; 0 download) Abstract Background. The cellular immune response is important in chronic hepatitis C (CHC). To better understand its mechanism, we examined dendritic cells (DCs) and hepatitis C virus (HCV)-specific cytotoxic T cells (CTLs), which are thought to contribute to liver injury and viral clearance. Methods. CHC patients received 24 weeks of interferon-a-based antiviral therapy. We analyzed time-sequential frequencies of peripheral DCs, classified as myeloid DCs (mDCs) or plasmacytoid DCs (pDCs), together with peptide major histocompatibility class I tetramers, epitope specific for HCV core 129–137 (t*24/c129) or HCV NS3 1296–1304 (t*24/ns1294), directly ex vivo. Results. The mDC and pDC populations changed in parallel (P < 0.05), showing a significant transient decrease at weeks 12 and 16 during the therapy, and then recovering. However, neither of the tetramer results showed a direct correlation with the kinetics of peripheral DCs. Conclusions. There is an apparent effect of antiviral therapy or a subsequent reduction of HCV on host immunity, but the effect may not include the induction of CTLs in CHC. [validation ref - 6] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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