Detail Mapping and characterization of B cell linear epitopes in the conservative regions of hepatitis C virus envelope glycoproteins (from Journal of Viral Hepatitis, 2002, 8, 174-182) Bibliografi Author: Olenina, L. V. ; Nikolaeva, L. I. ; Sobolev, B. N. ; Blokhina, N. P. ; Archakov, A. I. ; Kolesanova, E. F. Topik: HCV; Envelope; Epitope mapping; Pepscan; Validation ref - 9; 11; 12 Bahasa: (EN )     Penerbit: Blackwell Science Ltd     Tahun Terbit: 2002     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: olenina2002.pdf (136.49KB; 0 download) Abstract SUMMARY. Forty-eight overlapping octapeptides covering highly conservative regions of E1 and E2 hepatitis C virus (HCV) envelope proteins were synthesized and tested by ELISA against different groups of sera obtained from HCVinfected patients. All sera from patients with acute infection, except a single case of serum reactivity with the region HINRTALN, were nonreactive with any peptide. Sera obtained from chronic patients reacted with 12 peptides from five selected regions. Two immunodominant B epitopes were found, one being the precisely mapped antigenic site RMAWDM positioned inside the earlier shown immunodominant epitope from E1, and the second site, PALSTGLIH from E2, detected for the first time. New minor antigenic site was determined as PTDCFRKH from E2. We found only minor seroreactivity for one of the putative sites involved in CD81 binding, PYCWHYAP. [validation ref - 9, 11, 12] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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