Detail Concomitant Augmentation of Type 1 CD4+ and CD8+ T-Cell Responses During Successful Interferon-(alpha) and Ribavirin Treatment for Chronic Hepatitis C Virus Infection (from Human Immunology 2003, Vol. 64, 497-504) Bibliografi Author: Sreenarasimhaiah, Jayaprakash ; Jaramillo, Andres ; Crippin, Jeffrey ; Lisker-Melman, Mauricio ; Chapman, William C. ; Mohanakumar, T. Topik: CD4(alpha) T cells; CD8(alpha) T cells; hepatitis C virus; IFN-(alpha)/ribavirin therapy; Validation ref - 2; 20 Bahasa: (EN )     Penerbit: Elsevier     Tahun Terbit: 2003     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: sreenarasimhaiah2003.pdf (176.99KB; 0 download) Abstract The combined interferon-(alpha_ (IFN-alpha)) and ribavirin (IFN-(alpha)/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%–64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The objective of this study was to further define the effect of IFN-(alpha)/ ribavirin therapy on type 1 and type 2 HCV-specific CD4(alpha) and CD8(alpha) T-cell responses during IFN-(alpha)/ribavirin therapy. Toward this, serial CD8(alpha) T-cell responses to HCV-derived epitopes and CD4(alpha) T-cell responses to the HCV core antigen were analyzed in four patients before(baseline), during (at 24 weeks), and at the end (at 48 weeks) of IFN-(alpha)/ribavirin therapy. Therapy-induced viral clearance in three patients was associated with a significant augmentation of HCV-specific type 1 CD4(alpha) and CD8(alpha) T-cell responses. In contrast, in a patient who did not respond to therapy, a significant HCV-specific CD4(alpha) Th2 cell reactivity was observed accompanied by a lack of augmentation of the HCV-specific CD8(alpha) T-cell reactivity. These results indicate that enhancement of HCVspecific CD4(alpha) and CD8(alpha) T-cell responses is an important factor in determining the response to the IFN-(alpha)/ribavirin therapy and the outcome of the HCV infection. [validation ref - 2, 20] Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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