Atherosclerosis belongs to inflammation related vascular diseases due to bacterial infection and causes lipid accumulation in artery wall that lead to heart attack and stroke. Matrix
metalloproteinase (MMP)-2 and -9 are grouped to zinc-dependent proteases that act in degradation of extracellular matrix in atherosclerotic plaque. Instead of traditional
foods, the rhizomes of Zingiberaceae have been empirically used in folk medicines purposes,including natural vascular protection. This study was aimed to test the inhibitory effect of
10 Zingiberaceae rhizomes on the expression of MMP-2 activity in lipopolysaccharide-induced
artery endothelial cellsby conducting gelatin zymogram. At 1 µ g/ml, selected
Zingiberaceae rhizomes, i.e. Kaempferia pandurata, Curcuma xanthorrhiza, Alpinia galanga, Zingiberaceae officinale,and Z. officinaleVar Rubra, were found to attenuate MMP-2 activity up to 50% compared with LPS-treated cells. In summary, these data suggest that selectedZingiberaceae rhizomes may be applied for potential therapeutics in vascular protection and therapy, in particular atherotherapy. |