Uji Efektivitas In Vito dan In Vivo Perlindungan terhadap Sinar Mtahari Sediaan Krim O/w dan W/o yang Mengandung Kombinasi Rutin dan Etil Para Metoksisinamat  

Oleh:

Windono, Tri ; Avanti, Christina ; Wibowo, Purnomo Hadi ; Dwiyanti, Maya ; Budipratiwi

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Ilmiah Sains dan Teknologi vol. 01 no. 02 (Feb. 2006), page 87-92.
Topik: EPMS; Rutin; SPF; %TE; %TP

Ketersediaan

Perpustakaan PKPM Nomor Panggil: J110 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This studyies conducted to determine the sun protection efficacy of creams containing rutin and etil paramethoxycinnamate (EPMS) in combination by in vitro and in vivo test. The in vitro parametre was percentage of erythema transmittance (%ET), percentage of pigmentation transmittance (%PT) nad in vitro Sun Protection Factors (SPF) value whice is obataion from UV spectra profile of solution in isopropanol and etanol 909%. The in vivo parameter for efficacy was in vivo SPF value whice is obtain throught comparing the time to reach the MED on protected guinea pig skin with sunscreen and unportected skin. The result of this in vitro test for O/W crean was %ET = 6,2%; %PT = 19,58; in vitro SPF = 88,44 and for W/O cream was %TE = 6,10; %TP = 30,0; in vitro SOF =75,08. while in the in vbivo test for 24 hours observation until the UV exposed of finised. This in vivo study used guinea pig with specific criteria from this in vivo efficacy test, the in vivo SPF value obtained is 14 for O/W cream and 15 for W/O cream. In conclusion, w/o cream containing rutin and EPMS in combination has better efficacy than o/w cream.

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