Detail CD44 Variant 6 is Involved in Peritoneal Dissemination and Poor Prognosis in Patients with Advanced Epithelial Ovarian Cancer Bibliografi Author: Tjhay, Francisca Topik: OVARIAN CANCER; Cancer stem cell; CD44; ovarian cancer; peritoneal metas-tasis; prognosis Bahasa: (EN )     Penerbit: Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University     Tempat Terbit: Kumamoto    Tahun Terbit: 2015     Jenis: Theses - Dissertation Ketersediaan Perpustakaan FK Nomor Panggil: MD-FK-029 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Cancer stem cells (CSCs) drive tumor metastasis in several types of human cancer. In epithelial ovarian cancer, the CSCs contribution of peritoneal metastasis has remained unclear. The cell adhesion molecule CD44 has been identified as a major marker for CSCs in solid tumors, including ovarian cancer. CD44 exists as a standard form (CD44s) and also as numerous variant isoforms (CD44v) generated by alternative mRNA splicing. Here I show that disseminated ovarian tumors in the pelvic peritoneum contain highly enriched CD44v6-positive cancer cells, which drive tumor metastasis. Clinically, an increased number of CD44v6-positive cancer cells in primary tumors was associated with a shortened overall survival in stages III-IV ovarian cancer patients. In addition, a subpopulation of CD44v6-positive cancer cells manifested the ability to initiate tumor metastasis in the pelvic peritoneum in an in vivo mouse model, suggesting that CD44v6-positive cells show the potential to serve as metastasis-initiating by the CD44v6-positive subpopulation, and CD44v6 expression is a biomarker for the clinical outcome of advanced ovarian cancer patients. Given that a distinct subpopulation of CD44v6-positive cancer cells plays a critical role in peritoneal metastasis, definitive treatment should target this subpopulation of CD44v6-positive cells in ovarian cancer. Related courses MED 308 - I KEBIDANAN& PENY.KANDUNGAN I (Bacaan Anjuran) MED 437 - I KEBIDANAN& PENY.KANDUNGAN I (Bacaan Anjuran) MED 438 - I KEBIDANAN& PENY.KANDUNGAN II (Bacaan Anjuran) MED 648 - ILMU KEBIDANAN & PENY. KANDUNGAN (Bacaan Anjuran) Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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