Everybody wants a good memory, because it’s very useful for our daily activities and it will support our life to become a better individual. One of those memories that is essential for our daily life is spatial memory,which uses our saved information to adjust our position and becomes a navigation system for our movement. In this opportunity, researcher will use lycopene extract which is one of the main antioxidant compound in tomatoes (Lycopersicum esculentum) to seek it’s effect on spatial memory function on C57BL/6 mice.
Objectives: The aim of this research is to determine the effect of lycopene extract on C57Bl/6 mice’s spatial memory.
Method: This research is an experimental study with two groups of mice, which is the control and lycopene group. Both group will be trained with Morris Water Maze (MWM) for five days with four trials per day, and will do the MWM examination on the next day (1st day) and after a complete three weeks of intervention, which is the 22nd day.
Result and Conclusion: There are no significant difference in escape latency (p = 0,556; p=0,05) and path length (p = 0,281; p=0,05) control groups. On the other side, lycopene group shows significant decrease on escape latency (p = 0,036; p<0,05) with no improvement on path length (p = 0,154; p=0,05). According to the result, lycopene group has a significant decrease on escape latency (p = 0,036; p<0,05) as compared to the control group (p = 0,556; p=0,05). This finding concludes that lycopene extract intervention have positive effect on C57BL/6 mice’s spatial memory. |