In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake  

Oleh:

Gurusinghe, Dumindra ; Gill, Sharan ; Almario, Rogelio U.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 04 (Mar. 2010), page 1192-1199.
Topik: Adrenal steroids; PCOS; obesity; insulin resistance; leptin

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate adrenal steroid regulation in polycystic ovary syndrome. Design Five-hour oral glucose tolerance test (OGTT) and frequently sampled-intravenous gluclose tolerance test. Setting University research center. Patient(s) Thirty patients. Intervention(s) None. Main Outcome Measure(s) Anthropometrics, leptin, cortisol, DHEAS, glucose, insulin. Result(s) Morning cortisol correlated with sensitivity index (SI, r = .540), DHEAS correlated inversely with age (r = -.6359), body mass index (BMI, r = -.6199), fat mass (r = -0.630), and leptin (r = -0.5676). Between the second and fourth hour of OGTT, cortisol changes (?) exhibited three patterns: I, responders (n = 9, ?: 10.7 ± 1.0 µg/dL); II, nonresponders (n = 10, ?: -3.5 ± 0.6 µg/dL); III, intermediates (n = 11, ?: 4.3 ± 1.0 µg/dL). Compared with nonresponders, responders were more obese (BMI: 37.0 ± 1.6 vs. 31.7 ± 1.8 kg/m2); had higher leptin (28.9 ± 1.7 vs. 24.1 ± 1.1 ng/mL), and lower DHEAS (133 ± 12 vs. 236 ± 32 ng/mL), higher glucose at 1 h of OGTT (195 ± 13 vs. 131 ± 12 mg/dL), higher area under the curve (AUC)Glucose (332 ± 20 vs. 265 ± 17 mg/dL), higher AUCInsulin (244 ± 50 vs. 125 ± 30 µU/mL), and lower nadir glucose (61 ± 2 vs. 70 ± 2 mg/dL). Conclusion(s) Obesity and insulin resistance are associated with lower morning cortisol and DHEAS but increased cortisol and DHEA responses after glucose ingestion. Morning steroid levels may not reflect the day-long exposure.

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