Efek ekstrak buah tomat (Licopersicum pyriforme) terhadap ekspresi kolagen tipe 1, MMP-I dan MMP-3 pada penuaan kulit  

Oleh:

Wahyono, Poncojari

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 24 no. 03 (Dec. 2008), page 97-105.
Topik: Lycopersicum pyriforme; tomato; MMP-i; MMP-3; collagen type-I

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Many theory and research was trying to explain the aging process. Free radical theory explained that all norma metabolism process in the body can produce free radical. These free radical can destroy the skin cell, and than the skin will start the aging process. The tomato extract has antioxidant such as lycopene, a-carotene and vitamin C. These antioxidant will prevent the activity of free radical, so that skin cell will not damage. The aims of this research were to study effect of tomato extract juice in preventing skin aging on wistar rats. Total of 25 rats were divided into 5 groups, consisted of 5 rats each. Group one was control group (D-O) rats were four months old, and the group two control of group rats were taken care of 4 months old until 7 months old (D-i), the other group which were under treatment classified into 3 groups. Group three were fed 7 g/kg/dayl body weight of tomato fruit extract, then taken care of 4 months old until 7 months old (D-2), group four were fed Ii g/kg/day/ body weight of tomato extract fruit, then taken care of 4 months old until 7 months old (D-3) and group five were fed 15 g/kg/day/ body weigh of tomato fruit extract, then taken care of 4 months old until 7 months old (D-4). Experiment design usedwas completely randomized design with five treatment and five replicates. The data were analyzed using analysis of Variance Statistics Methodand if there were differences among the treatments, The LSD Test was used. The expression of the collagen type-i, the MMP-i and MMP-3 level were examined by immunohistochemistry, and compared with control group. The result indicated that there were significant difference (P

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