Background : Drugs resistant in Acinetobacter baumannii was reported continues to increase and has become a serious problem in medical world. Resistant in A. baumannii is caused by its ability to produce an enzyme called Metallo-ß-lactamase. Therefore, conducted a study that aims to determine the prevalence of Metallo-ß-lactamase-producing A. baumannii from clinical specimens of Atma Jaya Hospital in 2014 until 2016.
Methodology : This study is a descriptive study to show the prevalence of MBL-producing Acinetobacter baumannii. The isolates was taken from clinical specimens of Atma Jaya Hospital from January 2014 untuil September 2016. The study was conducted in January until November 2016 in the Laboratory of Microbiology, Faculty of Medicine, Atma Jaya Cathholic University of Indoesia. MBL production test was conducted by MIC Test Strip MBL method.
Results :In January 2014 until September 2016, the most prevalence isolates found in the Laboratory of Microbiology Atma Jaya and listed in WHONET 5.6 are E. coli (n=271), S. aureus (n=172), K. pneumonia (n=115), A. baumannii (n=97), and P. aeruginosa (n=71). Clinical isolates with the most common A. baumannii are pus/abscess (34,78%), followed by sputum (26,09%), urine (8,70%), blood specimen (8,70%), feses (4,35%), sputum intubation (4,35%), and also bacterial isolates that came from hospital environment (13,04%). Prevalence of MBL-producing A. baumannii is 52,17% (n=12) and non-MBL-producing A. baumannii is 47,83% (n=11). Out of 12 isolates of MBL-producing A. baumannii, 10 isolates (83,33%) were resistant to imipenem and meropenem, 1 isolat (8,33%) resistant to meropenem, and 1 isolate (8,33%) was resistant to imipenem. Out of 11 isolates of non-MBL-producing A. baumannii, 5 isolates (45,45%) were resistant to imipenem and meropenem, 4 isolates (36,36%) were sensitive to imipenem and meropenem, and 2 isolates (18,18%) were sensitive to meropenem.
Conclusions : The prevalence of isolates of A. baumannii listed in WHONET 5.6 from January 2014 until September 2016 is 13,36%. The prevalence of MBL-producing A. baumannii is 52,17%. MBL-producing A. baumannii ioslates mostly came from pus/abscess. |