Status Gizi dan Funfsi Hati Mencit (Galur Cbs-Swiss) dan Tikus Putih (Galur Wistar) di Laboratorium Hewan Percobaan Pulitbang Biomedis dan Farmasi  

Oleh:

Sihombing, Marice ; Raflizar

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Media Penelitian dan Pengembangan Kesehatan vol. 20 no. 01 (Mar. 2010), page 33-40.
Topik: Mice; Albino Rats; Body Weight; Blood Test Parameters; Liver
Fulltext: M45 Vol 20, No 1 Mar (2010) p33.PDF (545.77KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: M45 Non-tandon: tidak ada Tandon: 1	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: M32.K.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Mice (CBS-Swiss strain) and albino rats (Wistar strain) are experimental animals bred and kept in Centre for Biomedical and Pharmaceuticals Research and Development, National Institute of Health Research and Development (NIHRD) Jakarta. The objective of this study is to elucidate the health profile of these animals and to assess their suitability as experimental animals. Parameters being measured include body weight gain, histopathology of the liver, blood test (SGPT, SGOT, billirubin scale)and internal organ weights (liver, kidney, lungs and lymph nodes). In this study, particularly for the body weight, used 180 mice and 180 rats, divided into 3 age groups 1, 2 and 3 months old Each age groups consisted of 60 animals (30 male and 30 female). For the measurement of blood test, weight of internal organs and histopathologic of the liver examination used 60 mice and 60 rats from these animals. Which are divided into 3 groups 1, 2 and 3 months old, each groups were composed of 20 (/0 male and 10 female animals). Mice and rats are taken at random sampling. Data analYlis were conductedby ANOVAone-way test, exceptfor organ weight (liver mid lungsfor mice and liver for albinorats) where data were analysed using a non-parametric test. Linear regression test was conducted for measurement of body weight gain in each age group. The result of the study suggested that the weight gain in mice and albino rats correlate with increasing of age. Histopathological assessment of liver did not show any cell damage or degeneration of parenchyma cells in both species. The blood test also showed normal values, and in general the organ weights (liver, kidney, lungs and lymphnodes) showed an increase that correlated with age. The study conclude that in general the conditions of these animals and their physiological state are good, and they are fit to be used as experimental animals.

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