Background: Interaction between cancer cell and peritumour stromal is known not only helps promoting the growth of cancer cells but also facilitates the metastatic of cancer cells, by means of activating the fibroblasts. The activated fibroblasts would undergo architectural changes which then can be compared with normal fibroblasts. This study would observe the changes in the stromal as a result of this interaction in cervical dysplasia lesion and squamous cell carcinoma of the cervix.
Methods: In this cross-sectional study, consecutive sampling was used as the method for sampling. CD34 was used as a marker to see the changes in the stroma between cervical dysplasia lesion and squamous cell carcinoma of the cervix. The CD34 expression was assessed semi-quantitatively as: 0 (negative), 1 (10-50%), and 2 (>50%).
Result: From 29 samples in total, 13 samples were cervical dysplasia lesions and 16 samples were squamous cell carcinoma of the cervix. The participants’ age ranged from 26-77 years old, with the highest frequency in the 40-44 years old age group. All 13 cervical dysplasia samples scored 2, while 15 out of 16 and squamous cell carcinoma of the cervix samples scored 0, with 1 sample scored 1.
Conclusion: There was a significant difference of stromal CD34+ expression between cervical dysplasia lesion and squamous cell carcinoma of the cervix. The stroma in squamous cell carcinoma of the cervix was found free of CD34+ expression. |