Immunosuppression Armamentarium in 2010: Mechanistic and Clinical Considerations  

Oleh:

Urschel, Simon ; Altamirano-Diaz, Luis A. ; Medico-Cirujano

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 57 no. 02 (Apr. 2010), page 433-457.
Topik: Immunosuppressive treatment; Pediatric transplantation; Solid-organ transplantation; Induction; Maintenance immunosuppression; Mechanism of action; Side effects

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Effective immunosuppression is the key to successful organ transplantation, with success being defined as minimal rejection risk with concomitant minimal drug toxicities. Despite the general recognition of this fact, a paucity of appropriate clinical trials in children has contributed to lack of standardization of clinical management regimens, resulting in an extensive diversity of favored approaches. Nonetheless, although consensus has not been reached on the ideal approach to immunosuppression in pediatric transplantation, new drug therapies have contributed to a continuing improvement in graft and patient survival. Future clinical research must focus on diminishing the extensive burden of toxicities of these therapeutic agents in children.

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