Perbandingan Daya Guna antara Dexmedetomidin 0,6 µg/kgBB Intravena dengan Fentanyl 1 µg/kgBB Intravena untuk Mengurangi Insiden Agitasi setelah Anestesi Sevoflurane pada Anak Usia 2-5 Tahun  

Oleh:

Pratata, Qurniawan ; Rahardjo, Sri ; Suwondo, Bambang Suryono

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Berkala Kesehatan Klinik vol. 15 no. 02 (Dec. 2009), page 79-86.
Topik: dexmedetomidin - fentanyl - agitation

Ketersediaan

Perpustakaan FK Nomor Panggil: B25.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Agitation is an adverse effect which frequently found in pediatrics after general anesthesia under sevoflurane. Dexmedetomidin had several effects as sedative, analgesia, reduce the sympathetic activity and also maintenance neurotransmitter regulation, therefore it could be a choice to reduce the incidence of agitation in pediatrics after general anesthesia under sevoflurane. Objective: The objective of the study is to investigate the efficacy of intravenous 0.6 µg/kgBW demedetomidin compared with intravenous 1 µg/kgBW fentanyl to reduce the incidence of agitation in 2 to 5 year-old pediatric patients after general anesthesia under sevoflurane. Methods: The design of this research is double blind randomized contolled trial. Subjects are 80 male and female patients, aged 2 to 5 year-old, physical status ASA I and II, underwent elective surgery under general anesthesia in the Surgery Center Building at Dr. Sardjito General Hospital and affiliated teaching hospitals. Subjects are divided into two groups, Group A and Group B. Each group consists of 40 patients. Midazolam 0.05 mg/kgBW is given in the preparation room to all patients in both groups. The anxiety score is evaluated with Ramsay score. In the operating room, 1 µg/kg BW fentanyl is given and followed by induction with inhalation of sevoflurane. Intubation is fascilitated with 0.5mg/kgBW atracurium, general anesthesia is maintained under O2 N2O and 2 volume % of sevoflurane. Around 10 minutes prior to the end of surgery, intravenous 0.6 µg/kgBW dexmedetomidin, and 1 µg/kgBW fentanyl is given to patients in Group A, and in Group B respectively. The time of full recovery and agitation are evaluated in the recovery room. Result and Conclusion: We find that there is a significant difference (p<0.05) between two groups in the term of the incidence of agitation. The incidence of agitation is 5% and 27.5% in Group A and in group B respectively. Therefore, it can be concluded that intravenous 0.6 µglkgBW dexmedetomidin is more efficacious to reduce the incidence of agitation after general anesthesia under sevoflurane in 2 to 5 year-old pediatric patients than intravenous 1 µg/kgBW fentanyl.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali