An Association Between Subclinical Hypothyroidism and Sight-Threatening Diabetic Retinopathy in Type 2 Diabetic Patients  

Oleh:

Jin-Kui, Yang ; Wei, Liu ; Jing, Shi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 05 (May 2010), page 1018-1020.
Topik: Sight-Threatening Diabetic Retinopathy

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE To determine the relationship between subclinical hypothyroidism (SCH) and the prevalence of diabetic retinopathy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS A total of 1,170 type 2 diabetic patients were screened for thyroid function. There were 127 type 2 diabetic patients with SCH and 200 randomly selected euthyroid type 2 diabetic patients selected. Those with more severe than moderate nonproliferative diabetic retinopathy were classified as having sight-threatening diabetic retinopathy (STDR). RESULTS The trend for severe retinopathy was significantly higher in the SCH group than in the euthyroid group (?2 = 20.43, P = 0.000). SCH was associated with greater prevalence of diabetic retinopathy, especially STDR [odds ratio (95% CI): 4.15 (2.17–7.96), P = 0.000] after an adjustment for age, sex, duration of diabetes, A1C, BMI, hypertension, and LDL cholesterol. Even euthyroid patients with thyroid-stimulating hormone levels between 2.0 and <4.0 µIU/ml had a higher rate of STDR then those between 0.4 and <2.0 µIU/ml (P = 0.008). CONCLUSIONS Type 2 diabetic patients with SCH are associated with an increased risk of STDR.

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