Expression of the Actin-binding Proteins Indicates that Cofilin and Fascin are Related to Breast Tumour Size  

Oleh:

Zhang, Y. ; Tong, X

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 03 (May 2010), page 1042-1048.
Topik: breast cancer; actin-binding proteins; cofilin 1; fascin; a-actinin-4; elongation factor 1-a2; tumour size

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of breast cancer (stages T0 – T1, T2 and T3) compared with normal control tissues (n = 33). Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. Significant up-regulation of cofilin 1 mRNA was associated with stages T0 – T1 and T2; up-regulation seen at stage T3 was not significant compared with control tissue. Fascin mRNA levels were significantly reduced at all three tumour stages (T0 – T1, T2 and T3) compared with control tissue. In conclusion, some components of the actin cytoskeletal system might hold significant potential as targets in future cancer therapies.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali