Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome  

Oleh:

Jin Ju, Kim ; Young Min, Choi ; Seon Ha, Choung

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 06 (Apr. 2010), page 1942-1947.
Topik: Estrogen receptor ß; gene; polycystic ovary syndrome; +1730 G/A polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-ß gene is associated with susceptibility to polycystic ovary syndrome (PCOS). Design Case–control study. Setting University Department of Obstetrics and Gynecology. Patient(s) Women with (n = 138) or without (n = 290) PCOS. Intervention(s) Genotyping was performed by polymerase chain reaction–restriction fragment-length polymorphism analysis. Main Outcome Measure(s) Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-ß gene. Result(s) There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes. Conclusion(s) The ER-ß gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS.

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