Early demonstration of postoperative adhesions in a rodent model  

Oleh:

Yelian, Frank D. ; Shavell, Valerie I. ; Diamond, Michael P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 08 (Jun. 2010), page 2734-2737.
Topik: Postoperative adhesions; angiogenesis; beta 1 integrin; fibronectin

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To assess the cellular and molecular mechanisms of postoperative adhesion development in a rodent model. Design Prospective randomized controlled study. Setting Research laboratory. Patients Thirty sexually mature female Sprague-Dawley rats. Interventions Cecal abrasion. Main outcome measure(s) At 0, 2, 4, 8, 16, 24, 48, 72, 96, 168, 336, and 504 hours after cecal abrasion, one to three rats were sacrificed (n = 26). Four nonabraded rats served as controls. Peritoneal adhesion status was evaluated and tissue was collected for histologic and immunohistochemical investigation. Results Postoperative tissue attachments were identified as early as 2 hours after cecal abrasion. Significant local edema and vessel congestion appeared within 2 hours, and cellular proliferation was observed at 24 hours; angiogenesis and tissue proliferation remained present at 2 weeks. ß1 integrin was highly expressed early and was thereafter decreased. Cellular fibronectin was not detectable until 1 week after cecal abrasion. Conclusions Postoperative adhesions are initiated as rapidly as 2 hours after surgical intervention in this rodent model.

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