Anti-ß2-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss  

Oleh:

Alijotas-Reig, Jaume ; Ferrer-Oliveras, Raquel ; Rodrigo-Anoro, Maria Jose

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2330-2336.
Topik: Antiphospholipid syndrome; antiphospholipid antibodies; anti-ß2GP1 antibodies; anti-cofactor syndrome; anti-phosphatidylserine; pregnancy loss; recurrent miscarriage

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the role of anti-ß2-glycoprotein-I (anti-ß2GPI-ab) and anti-phosphatidylserine (aPS-ab) antibodies as a risk factor in both recurrent miscarriage (RM) and unexplained fetal losses (UFL). Design Retrospective, cohort study. Setting Vall d'Hebron University Hospital, Barcelona, Spain. Patient(s) 122 pregnant women divided in two groups: study group of 54 women with RM and/or UFL and control group of 68 pregnant without RM history. Intervention(s) Analysis of lupus anticoagulant, anticardiolipin antibodies, and anti-ß2GP1 and aPS antibodies. Main Outcome Measure(s) Comparison of aPL antibody between groups. Result(s) The prevalence of aPL positive results was 8 out of 54 (14.8%) in the study group and 3 out of 68 (4.41%) in the controls. In the RM subgroup, the prevalence was 3 out of 25 (12%) versus 3 out of 68 (4.4%), and 7 out of 34 (20.6%) versus 3 out of 68 (4.4%) in UFL subgroup. As a whole, the prevalence of anti-ß2GP1-ab in the RM/UFL group showed a difference compared with controls but not aPS-ab. In the RM women, anti-ß2GP1-ab was positive in 3 out of 25 (12%) versus 1 out of 68 (1.5%) in controls and in 4 out of 34 versus 0 out of 68 cases in women with UFL. In the RM subgroup, aPS-ab was positive in 1 out of 25 (4%) versus 2 out of 68 (2.9%) in control group and in 3 out of 34 versus 2 out of 68 cases in women with UFL. Conclusion(s) Our results suggest that anti-ß2GP1-ab but not aPS-ab is related to RM/UFL and should be considered as a pregnancy-loss risk factor.

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