Increased circulating soluble P-selectin in polycystic ovary syndrome  

Oleh:

Yildiz, Bulent O. ; Bozdag, Gurkan ; Harmanci, Ayla

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2311-2315 .
Topik: Cardiometabolic risk; thrombosis; inflammation; platelets; endothelial cell

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine whether the P-selectin–von Willebrand factor (vWF) pathway is altered in patients with polycystic ovary syndrome (PCOS). Design Case-control study. Setting(s) Tertiary care academic medical center. Patient(s) Thirty-two normal glucose-tolerant patients with PCOS and 21 age- and body mass index–matched healthy women were prospectively enrolled. All the patients with PCOS had clinical and/or biochemical hyperandrogenism and chronic oligoanovulation, and 89% had polycystic ovaries on ultrasound. Intervention(s) None. Main Outcome Measure(s) Soluble P-selectin (sP-selectin), vWF, total T, sex hormone–binding globulin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, fasting glucose and insulin, 2-hour glucose, and homeostatic model assessment–insulin resistance. Result(s) Soluble P-selectin levels were significantly higher in patients with PCOS compared with controls (58.7 ± 19.0 vs. 45.3 ± 15.0 ng/mL), whereas PCOS and control groups had similar vWF levels (46.7 ± 24.2 vs. 39.5 ± 22.3, respectively). There was no correlation between sP-selectin and anthropometric measurements or any of the androgen, lipid, or insulin resistance parameters. Conclusion(s) Our results suggest increments in the circulating sP-selectin concentrations associated with unaltered vWF levels in PCOS. Increased sP-selectin might potentially contribute to the future risk of cardiovascular disease in patients with PCOS.

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