Effects of testosterone and metformin on glucose metabolism in endometrium  

Oleh:

Lei, Zhang ; Qinping, Liao

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2295-2298.
Topik: PCOS; metformin; endometrium; IRS-1; GLUT-4

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effects of testosterone and metformin on glucose metabolism in endometrium. Design In vitro experiment. Setting Reproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China. Patient(s) Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis. Intervention(s) Endometrial glandular epithelial cell culture. Main Outcome Measure(s) Insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT-4) expression in endometrial glandular epithelial cell. Result(s) After the action of testosterone solution, the protein expressions of IRS-1mRNA, IRS-1, and GLUT-4 in endometrial glandular epithelial cells all decreased significantly. Metformin may reverse this effect. Conclusion(s) The high androgen levels in patients with polycystic ovary syndrome could induce insulin resistance in endometrial glandular epithelial cell, whereas metformin has an antagonizing effect.

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