Predictors of urinary albumin excretion in women with polycystic ovary syndrome  

Oleh:

Duleba, Antoni J. ; Ahmed, Ibrahim M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2285-2290.
Topik: Polycystic ovary syndrome; urinary albumin; endothelial function

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate urinary albumin excretion (UAE) in normotensive and nondiabetic women with polycystic ovary syndrome (PCOS) in relation to their clinical, endocrine, and metabolic profiles. Design Observational study. Setting University fertility center. Patient(s) Sixty-three women with PCOS were evaluated. Intervention(s) Clinical assessments and urine and blood testing. Main Outcome Measure(s) Urinary albumin excretion, systolic and diastolic blood pressure, serum levels of LH, FSH, PRL, T, 17-hydroxyprogesterone, glucose, insulin, lipids, C-reactive protein, and 24-hour urinary free cortisol. Result(s) In univariate and multivariate correlation analysis, UAE correlated with diastolic blood pressure, insulin area under the curve during glucose tolerance test, PRL, and 17-hydroxyprogesterone. Overt microalbuminuria was detected in a significant proportion of subjects. Conclusion(s) Urinary albumin excretion in women with PCOS correlates well with other cardiovascular risk factors. Because the relationship between UAE and adverse cardiovascular events is continuous, evaluation of UAE in the presence of PCOS may provide clinically relevant information and may aid in selecting appropriate patients for more aggressive treatment of likely aggravating factors, such as hyperinsulinemia or borderline hypertension.

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