Does luteal estradiol supplementation have a role in long agonist cycles?  

Oleh:

Elgindy, Eman A. ; El-Haieg, Dahlia O. ; Mostafa, Magdy I.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2182-2188.
Topik: Luteal phase support; estradiol supplementation; GnRH agonist; ICSI cycles

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To test the hypothesis that the addition of 6 mg estradiol (E2) valerate either orally or vaginally to progesterone (P) for luteal support, can increase the probability of pregnancy in intracytoplasmic sperm injection (ICSI) cycles using the long agonist protocol. Design Prospective open-labeled randomized controlled trial. Setting Private and university fertility centers. Participant(s) Women undergoing ICSI cycles, with controlled ovarian hyperstimulation using long agonist protocol. Intervention(s) On embryo transfer day, participants were randomized to receive, only P (group A, n = 90), P along with 6 mg E2 valerate either orally (group B, n = 90), or vaginally (group C, n = 90) for luteal support. Main Outcome Measure(s) Clinical pregnancy was the main outcome. luteal serum E2 and P profiles were the secondary outcomes. Result(s) Highest pregnancy rate was achieved in group C (45.56%), it was significantly higher than A (relative risk 1.52, 95% CI: 1.03 to 2.24). Day 0 (hCG day) E2 levels were similar in the three groups. Group A had lower E2 levels on days 7, 10, and 13 and a higher magnitude of E2 decline on days 7 and 10. Similar levels of luteal E2 were documented in groups B and C. P levels were similar in the three groups. Conclusions(s) Addition of 6 mg E2 valerate to P support may encumber the sharp decline in luteal E2 level. It may enhance the probability of pregnancy if administered vaginally.

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