Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium  

Oleh:

Mehasseb, Mohamed Khairy ; Bell, Stephen Charles ; Pringle, James Howard

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 07 (May 2010), page 2130-2136.
Topik: Electron microscopy; ultrastructure; uterus; adenomyosis; junctional zone; myometrium

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To study the ultrastructure of the inner and outer myometrium, in the presence and absence of uterine adenomyosis. Design Case control blinded comparison. Setting University departments. Patient(s) Four premenopausal women with and six without uterine adenomyosis as the sole pathology. Intervention(s) Multiple samples were studied using transmission electron microscopy. Main Outcome Measure(s) Ultrastructure feature of the myometrium. Result(s) In uteri with adenomyosis, the myocytes exhibited cellular hypertrophy. The cytoplasmic myofilaments were less abundant. Abundant intermediate filaments formed cytoplasmic aggregates. The nuclei had a smooth outline with a clear ground substance, prominent nucleoli and peripherally arranged nuclear chromatin. There was occasional infolding of the nuclear envelope with entrapment of cytoplasmic organelles. The sarcolemmal bands were significantly longer and there were fewer caveolae. The perinuclear cell organelles were more distinct. The rough endoplasmic reticulum and Golgi apparatus were more prominent, denoting active protein synthesis, consistent with the observed cellular hypertrophy. All features were more prominent at the junctional zone. Conclusion(s) Smooth muscle cells from uteri with adenomyosis are ultrastructurally different from smooth muscle cells of normal uteri. These distinct features suggest a possible effect on myometrial contractility, together with hypertrophy.

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