Expression of angiopoietins 1, 2 and their common receptor tie-2 in relation to the size of endothelial lining gaps and expression of VEGF and VEGF receptors in idiopathic menorrhagia  

Oleh:

Mints, Miriam ; Blomgren, Bo ; Palmblad, Jan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 02 (Jul. 2010), page 701-707 .
Topik: Angiogenesis; endometrium; menorrhagia; gaps; VEGF; angiopoetin-1; angiopoetin-2; tie-2; pericytes

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether idiopathic menorrhagia (IM) is associated with alterations of the vascular expression of angiopoietin-1, angiopoietin-2, and tie-2 receptor. Design Prospective clinical study. Setting University Hospital, Department of Gynecology. Patient(s) Twenty-four patients with IM and 18 women with eumenorrhea. Intervention(s) Endometrial samples underwent immunohistochemical staining for CD34, angiopoetin-1, angiopoietin-2, tie-2, and smooth muscle actin-a. Previously published data on gap size and expression of vascular endothelial growth factor family members were used. Main Outcome Measure(s) Differences in immunostaining for these markers by computer-assisted stereological analysis. Result(s) There was significantly more angiopoetin-1 positive vessels in IM in the secretory phase, but not of angiopoetin-2 and tie-2, compared with controls. Densities of angiopoetin-1 positive vessels correlated significantly to those of angiopoetin-2 and vascular endothelial growth factor receptor 3. Smooth muscle actin-a positive pericytes covered the gaps. Double staining for CD34 and tie-2 receptor was partly identical, but gaps were covered by tie-2 stain. Conclusion(s) The discrete deregulation observed of the angiopoetin-1 expression before menstruation might affect vascular integrity, thereby contributing to the excessive blood loss in IM.

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