Care of women with XY karyotype: a clinical practice guideline  

Oleh:

Jorgensen, Pernille Bach ; Kjartansdottir, Kristín Ros ; Fedder, Jens

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 01 (Jun. 2010), page 105-113.
Topik: XY females; Swyer syndrome; Morris syndrome; gonadal dysgenesis; androgen insensitivity syndrome; infertility; malignancies; androgen receptor

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To provide an evidence-based guideline for professionals working with XY women. Design Review including patient cases from a Danish fertility clinic. Setting University-associated scientific unit and fertility clinic. Patient(s) Three selected cases. Intervention(s) None. Main Outcome Measure(s) Evaluation of etiology, diagnosis, treatment, and associated disorders in XY women. Result(s) Many gene mutations can cause abnormal fetal development leading to androgen insensitivity syndrome or gonadal dysgenesis disorders. Females with these disorders have an XY karyotype but look like girls. They are mostly diagnosed at puberty, and the condition will often lead to serious psychological problems. Increased risk of malignancies and problems with pregnancy and infertility are other aspects that should be considered. This guideline will aid doctors in caring for XY females. Conclusion(s) A precise diagnosis is important, because the treatment possibilities (e.g., use of allogenic oocytes) depend on the subgroup to which the XY female belongs.

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