Uji Farmakokinetik Pelet Ibuprofen Untuk Pelepasan Di Kolon Pada Tikus Wistar Normal  

Oleh:

Rachmawati, Heni ; Ramdani, Fiana ; Anggadiredja, Kusnandar ; Tjahjono, Darjono H.

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: MEDICINUS (Scientific Journal of Pharmaceutical Development and Medical Application) vol. 23 no. 02 (Jun. 2010), page 30-34.
Topik: colonic targeting; ibuprofen; pellets; pharmacokinetic; oral absorption

Ketersediaan

Perpustakaan FK Nomor Panggil: M56.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Backgrounds and purpose: Delivery systems of drugs through oral routes is the main op¬tion in the process of developing drug dosage forms. In general, oral administration of drugs, especially for systemic purposes will be released and/or absorbed in the upper part of gastrointestinal tract (GIT), i.e. stomach and small intestine. However, due to the intrinsic limitations of the drug substance and physiology of the digestive tract it is often a prohibitive factor. Colonic drug delivery system is an alternative system, currently developed. In addition to local goals, drug delivery through the colon can also be useful for systemic treatment purposes, especially for macromolecule compounds and other difficult-to-formulate drugs. The aim of this study is to evaluate the pharmacokinetic profile of ibuprofen pellets preparation for release in the colon, from the formula we previously developed. Method: Pharmacokinetic study was done by 2-cross over design methods. In vivo test performed on healthy rats, male, Wistar strain. After giving a single oral dose of ibuprofen (1.8 mg/200 g of body weight), 0.5 mL plasma was taken from the tail vein at 15 minutes before adminis¬tration and 0.25, 0.5, 1,3,5,8, 12, and 15 hours after administration. Ibuprofen content in plasma was carried out using high perform¬ance liquid chromatography using RP-18 column, mobile phase ace¬tonitrile-0.1 % acetic acid (3:2 v/v), flow rate 1.2 mL/min with a UV detector at wavelength of 220 nm. Results: T max of ibuprofen pellet was higher when compared to conventional preparation (suspension). Whereas the total C max and AUC (Area Un¬der Curve) between ibuprofen from pellet and suspension were not significantly different. Conclusion: Ibuprofen pellets for colonic targeting are retained for release in the upper part of GIT while released in the colon with a similar degree of absorption. This result concludes that our developed formula for ibuprofen is prospective as an alternative delivery system for ibu¬profen.

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