Aspek Onkologi Human Papillomavirus  

Oleh:

Rusmana, Djaja

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Kedokteran MARANATHA vol. 9 no. 1 (Jul. 2009), page 97-103.
Topik: papillomavirus; cervical cancer; cellular tumor suppressor proteins

Ketersediaan

Perpustakaan FK Nomor Panggil: J24.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Papillomaviruses are a diverse group of DNA-based viruses that may infect the skin and mucous membranes of humans and a variety of animals. There are over 100 different human papillomavirus (HPV) types that have been identified. Human papillomavirus (HPV) is a causal factor in the development of cervical cancer. However, the HPV' s mechanism of carcinogenesis has not been completely identified. The possibility of evolving HPVs into the direction of malignancy will depend on several factors, i.e. the type of the virus, the host and the environment, all of which are able to modify the course of HPV infection. Based on the epidemiological classification, HPVs can be divided into the high-risk and low-risk types. The high-risk types have a marked tendency to integrate in the host genome. The integration process may cause the interruption of E2 gene, which has the consequence of losing its control over E6 and E7 expressions. Moreover, E6 and E7 products will interact with and inhibit the function of the cellular tumor suppressor proteins (p53 and pRB).

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