ANGIOGENESIS: Patofisiologi dan Aplikasi Klinis  

Oleh:

Sardjono, Caroline T. ; Sandra, Ferry

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Kedokteran MARANATHA vol. 8 no. 2 (Feb. 2009), page 174-187.
Topik: angiogenesis; angiogenic factors; VEGF; FGF; TGF; angiopoietin

Ketersediaan

Perpustakaan FK Nomor Panggil: J24.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Angiogenesis is a process of new blood vessel development from pre-existing vasculature. The process plays an essential role in the normal growth of tissues, wound healing, tissue regeneration following cardiovascular events, and even during female reproductive cycles (i.e. menstruation and placental development). Under these conditions, angiogenesis is highly regulated by angiogenic factors. Several angiogenic factors, such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF), Transforming Growth Factor (TGF), and angiopoietin, have extensively been studied and have been used to treat many diseases. However, persistent unregulated angiogenesis has also been shown to contribute to many diseases such as tumor metastases, rheumatoid arthritis, and diabetic retinopathy. Continued advances in understanding the mechanism of the angiogenic process may provide further diagnostic and therapeutic benefits in dealing with a variety of diseases.

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