Cancer Immunology: From Immunosurveillance to Immunoescape  

Oleh:

Kresno, Siti Boedina

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Cancer vol. 02 no. 01 (Jan. 2008), page 18-23.
Topik: immunosurveillance; immunoescape; immunoediting

Ketersediaan

Perpustakaan FK Nomor Panggil: I12.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The immune system can specifically identify and eliminate tumor cells on the basis of their expression of tumor specific antigens or molecules induced by cellular stress. This process is referred to as tumor immunosurveillance, whereby the immune system identifies cancerous and precancerous cells and eliminates them before they can cause harm. The central roles of immune effector cells, such as B, T, natural killer cells (NK and NKT), IFN, perforrins and granzymes have long been clarified in cancer immunosurveillance. However, despite tumor imunosurveillance, why do tumors develop and flourish in a fully functional immunocompetent host? There has been a growing recognition that immunosurveillance represents only one dimension of the complex relationship between the immune system and cancer. Recent studies has shown that the immune system may also promote the emergence of primary tumors with reduced immunogenecity that are capable of escaping immune recognition and destruction. These findings lead to the development of the cancer immunoediting hypothesis. This review will summarize the interaction of host and tumor cells leading to elimination, equilibrium and escape, which is known as the 3E of the immunoediting process.

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