ESTROGEN EFFECTON VAGINAL EPITHELIUM IN WISTAR RATS  

Oleh:

Noegroho, Bambang S. ; Sugandi, Suwandi ; Surur, Abu

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 17 no. 02 (Jul. 2010), page 58-60.
Topik: Estrogen; vaginal epithelium; epithelial layer; estrogen replacement therapy; lower urinary tract symptoms

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To study the effect of estrogen on vaginal epithelium. Material & method: We divided 30 female wistar rats into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars served as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A paired T-test was used for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in the vagina. The mean thickness of epithelial layer in the vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared with the control group (p>0, 05), while the first group showed insignificant difference compared with the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect.

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