ANGIOTENSIN II TYPE-1 RECEPTOR (AT1R) DISTRIBUTION IN BPH, HIGH GRADE PIN AND ADENOCARCINOMA OF THE PROSTATE  

Oleh:

Septiadi, Isdianto ; Sugandi, Suwandi ; Noegroho, Bambang S.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 17 no. 02 (Jul. 2010), page 55-57.
Topik: Angiotensin IL high grade PIN; adenocarcinoma of the prostate

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: The aim of the study was to detect the differences in number and distribution of angiotensin II type- 1 receptor (AT1R) in BPH, high grade PIN, and adenocarcinoma of the prostate. Material & method: A prospective study was performed in RSHS, in collaboration with the Department of Anatomical Pathology. Prostate samples were taken by TUR of the prostate, and then divided into 5 groups. They were BPH, high grade PIN, adenocarcinoma of the prostate in 3 difference grades (well, moderate, and poorly differentiated). Kidney tissue served as control. Immunohistochemical staining was done to determine the angiotensin II type-1 (AT1R) receptor distribution as primary antibody mouse monoclonal antibody AT1 (TONI-1) was used. Results: Angiotensin II type-1 receptor was found in specimen from BPH, high grade PIN and adenocarcinoma of the prostate. The number and distribution of the receptors were not different. Conclusion: No significant differences in number and distribution of angiotensin II type- 1 receptor on BPH, high grade PIN, and adenocarcinoma of the prostate were found.

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