PERBEDAAN JUMLAH SEL TROFOBLAS YANG MENGALAMI APOPTOSIS PADA KEHAMILAN NORMAL DAN PRE EKLAMPSIA/EKLAMPSIA  

Oleh:

Keman, Kusnarman ; Prasetyorini, Nugrahanti ; Langgar, Madeline J.

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 24 no. 02 (Aug. 2008), page 79-85.
Topik: trophoblast; apoptotic process; p53; Bcl-2; preeclampsia/ eclampsia

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Hypoxia exposed trophoblast cells will cause apoptotic process, that correlate with up-regulation of p53 and Bax protein expression; and down-regulation of anti-apoptotic Bcl-2 protein. Apoptotic process and up-regulation of p52, and down-regulation of anti-apoptotic Bcl-2; also find both on trophoblastic sample from preeclampsia/ eclampsia complicated pregnancy, and normal pregnancy. The aim of this study is, to prove that the amount of apoptotic trophoblast cells on trophoblast tissue sample from preeclampsia/ ecclampsia complicated pregnancy, were higher then those of normal pregnancy. This research was laboratory cross sectional study, that observed immunohystochemically, p53 and BCI-2 protein expression; also the DNA-fragmented technically (TUNEL) to detect apoptotic cells on trophoblastic samples from preeclampsia/ eclampsia complicated pregnancy, compare by the normal pregnancy. On this study, we found that the amount of trophoblast cells that expressed of p53 protein (22.70 ± 2.90), were higher then those of normal pregnancy. (8.2 ± 4.99). The different was statistically significant. (t test; p d" 0.000). We also found that an apoptotic process on trophoblast cells of preeclampsia/ eclampsia placenta (15.3 ± 3,56) were higher then those of normal pregnancy (4.7 ± 1.89). The different was statistically significant. (t test; p d" 0.000). While the amount of trophoblast cells expressed of Bcl-2 protein, were higher on trophoblast tissue sample from normal pregnancy (20.3 ± 5.77) then those of preeclampsia/ eclampsia (9.9 ± 1.91). The different was statistically significant. (t test; p d" 0.000). This finding conclused, that the amount of trophoblast cells that were apoptotic on trophoblast tissue of preeclampsia/ eclampsia complicated pregnancy, were higher then those of normal pregnancy.

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