Subthalamic nucleus stimulation in Parkinson disease induces apathy  

Oleh:

Jeune, F. Le ; Drapier, D. ; Bourguignon, A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 73 no. 21 (Nov. 2009), page 1746-1751.
Topik: Parkinson disease; subthalamic nucleus deep brain stimulation; Trail Making Test; Wisconsin Card Sorting Test

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K.2009.08 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy induced by STN-DBS correlates with changes in glucose metabolism, using 18FDG-PET. Methods: Twelve patients with PD were assessed 3 months before (M–3) and 3 months after (M+3) STN-DBS with 18FDG-PET and the Apathy Evaluation Scale. Results: Apathy had significantly worsened at M+3 after STN-DBS. Positive correlations were observed between this variation in apathy scores and changes in glucose metabolism, especially in the right frontal middle gyrus (Brodmann area [BA] 10) and right inferior frontal gyrus (BA 46 and BA 47). Negative correlations between the two were observed in the right posterior cingulate gyrus (BA 31) and left medial frontal lobe (BA 9). Conclusion: These preliminary results confirm the role of the subthalamic nucleus in associative and limbic circuitry in humans and suggest that it is a key basal ganglia structure in motivation circuitry.

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