Aim.
This study was intended to know the changes of the liver stiffness by transient elastography (TE) and APRI before and after treatment at least one year in HBV patients for monitoring the treatment result and correlation between TE and APRI.
Method.
Data where collected from 41 HBV patients with and by using before-and-after treatment method to assess the changes of the liver stiffness and APRI after one year of treatment. The patients were performed TE and APRI before and after one year treatment. The patients were excluded if had infection of HVC or HIV, failure of the procedure, the worsening of hepatitis like acute excacerbation and HCC.
Results.
The median liver stiffness measured by TE was significantly decreased from 10,8 kPA to 5,9 kPA after one year of antiviral treatment with p<0,001. The median value of APRI before treatment was 1,13 and decreased significantly after treatment to 0.43 and with p<0,001. The correlation between liver stiffness and APRI before treatment were moderate with r=0,399 and after treatment the correlation were stronger with r=0,731.
Conclusion.
The liver stiffness that measured with transient elastography and APRI significantly decrease after one year of antiviral treatment in chronic HBV patients. There was a moderate correlation between TE and APRI before treatment and strong correlation after one year of treatment. |