Screening for intracranial aneurysms in patients with bicuspid aortic valve  

Oleh:

Schievink, Wouter I. ; Raissi, Sharo S. ; Maya, M. Marcel ; Velebir, Arlys

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 74 no. 18 (May 2010), page 1430-1433.
Topik: autosomal dominant polycystic kidney disease; bicuspid aortic valve

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: Bicuspid aortic valve (BAV) is a common congenital heart defect affecting half to 2% of the population. A generalized connective tissue disorder also involving the intracranial arteries has been suspected in this patient population. We therefore screened a group of patients with BAV for the presence of intracranial aneurysms. Methods: Magnetic resonance angiography or CT angiography of the brain was used in 61 patients with BAV (age, 29–70 years [mean 48 years]) and in 291 controls (28–78 years [mean 56 years]). Results: Intracranial aneurysms were detected in 6 of 61 patients with BAV (9.8%; 95% confidence interval [CI] 2.4%–17.3%). This was significantly higher than in the control population (3/291 [1.1%; 95% CI 0%–2.2%]) (p = 0.0012). Female sex (p = 0.02) and advanced age (p = 0.003), risk factors for intracranial aneurysm development, were more common in the control population than among the patients with a BAV. No significant differences were detected in age, sex, smoking, arterial hypertension, alcohol use, aortic diameter, or frequency of aortic coarctation between BAV patients with and without intracranial aneurysms. Conclusion: In this case-control study, the frequency of intracranial aneurysms among our bicuspid aortic valve patient population was significantly higher than in the control population.

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