Stimulus-Specific Oscillations in A Retinal Model  

Oleh:

Kenyon, G. T. ; Travis, B. J. ; Theiler, J. ; George, J. S. ; Stephens, G. J. ; Marshak, D. W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: IEEE Transactions on Neural Networks vol. 15 no. 5 (Sep. 2004), page 1083-1091.
Topik: MODEL; stimulus - specific; oscillations; retinal model

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: II36.11 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

High-frequency oscillatory potentials (HFOPs) in the vertebrate retina are stimulus specific. The phases of HFOP s recorded at any given retinal location drift randomly over time, but regions activated by the same stimulus tend to remain phase locked with approximately zero lag, whereas regions activated by spatially separate stimuli are typically uncorrelated. Based on retinal anatomy, we previously postulated that HFOP s are mediated by feedback from a class of axon - bearing amacrine cells that receive excitation from neighboring ganglion cells - via gap junctions-and make inhibitory synapses back onto the surrounding ganglion cells. Using a computer model, we show here that such circuitry can account for the stimulus specificity of HFOP s in response to both high - and low - contrast features. Phase locking between pairs of model ganglion cells did not depend critically on their separation distance, but on whether the applied stimulus created a continuous path between them. The degree of phase locking between spatially separate stimuli was reduced by lateral inhibition, which created a buffer zone around strongly activated regions. Stimulating the inhibited region between spatially separate stimuli increased their degree of phase locking proportionately. Our results suggest several experimental strategies for testing the hypothesis that stimulus-specific HFOPs arise from axon - mediated feedback in the inner retina.

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