Detail Gambaran Histopatologik dan Derajat Fibrosis Jaringan Hati Kolestasis Esktrahepatik Akut dan Kronik pada Tikus Sprague-Dawley Jantan Bibliografi Author: JULIO, OVAMELIA ; Harjanti, Dyonesia Ary (Advisor); Sidharta, Veronika Maria (Examiner) Topik: LIVER; acute ectrahepatic choletasis; chronic extrahepatic choletasis; histopathologic; fibrosis grade kolestasis ekstrahepatik akut; kolestasis ekstrahepatik kronik; histopatologic; derajat fibrosis Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2014     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: Ovamelia_Julio_KTI_2014.pdf (2.16MB; 1 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-773 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Background: Extrahepatic cholestasis is 70% of cholestasis cases and a severe pathological condition that can lead to terminal liver disease, morbidity and mortality. This research is conducted to evaluate histopathological features and fibrosis degree of acute and chronic extrahepatic choletasis in male Sprague-Dawley rats. Methods: Experiment design is qualitative experiment. Amount of 20 male 8 weeks Sprague-Dawley rats weight 200-250 grams divided into: 3 days sham-operated (SO3), 3 days post bile duct ligated (BDL3), 21 days sham-operated (SO21) and 21 days post bile duc ligated (BDL21). Liver tissues are evaluated macroscopically, microscopically and based on fibrosis degree with Hematoxillin-Eosin and Masson's trichrome staining. The mean difference of liver mass, biliary ductules and ducts increment, and portal area enlargement are tested with Mann-Whitney test. Result: Macroscopical feature of BDL3 shows color changes paler with rough spots. This group show 2 samples with portal fibrosis (10%) and 3 samples with septa (15%). Macroscopical feature of BDL21 shows color change paler with green cyst. This group shows 3 samples with portal fibrosis with septa (15%) and 1 sample in bigger area (5%). Liver mass BDL21 increase higher significantly than BDL3 (p=0.032). Histopathological changes include biliary ductules/ducts increment, portal area enlargement, necroinflamation, and sinusoid edema. Biliary ductules/ducts amount of BDL21 and BDL3 increase significantly (p=0.000). Portal area enlargement of BDL21 is higher than BDL3 (p=0.032) Conclusion: Histopathological feature and fibrosis degree of chronic extrahepatic cholestasis shows higher tissue damage than acute extrahepatic choletasis. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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