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Khasiat Biji Trigonella foenum graecum (Fenugreek) dalam Tatalaksana Diabetes Melitus Tipe 2
Bibliografi
Author:
FINDORO, MARIA DOMINIKA ANKIRA
;
Kurniawan, Sandy Vitria
(Advisor);
Setiadi, Hermawan
(Examiner)
Topik:
HERBAL MEDICINE
;
Trigonella foenum graecum
;
diabetes mellitus
Bahasa:
(ID )
Penerbit:
Fakultas Kedokteran Unika Atma Jaya
Tempat Terbit:
Jakarta Utara
Tahun Terbit:
2015
Jenis:
Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK)
Fulltext:
Maria_Dominika_Ankira_Findoro_KTI_2015.pdf
(1.63MB;
1 download
)
Ketersediaan
Perpustakaan FK
Nomor Panggil:
KTI-FK-759
Non-tandon:
tidak ada
Tandon:
1
Lihat Detail Induk
Abstract
Diabetes mellitus type 2 is the disease which attact million people worldwide nowadays. Various management are being developed to treat this disease, one of them is herbal remedies. One of the herbs being developed for the treatment of type 2 diabetes mellitus is Trigonella foenum graecum, also known as ‘fenugreek’ or ‘kelabat’. The effectiveness of Trigonella foenum graecum about its effect to lowering the level of blood sugar has been studying for a long time. This literature study aims to determine the mechanism of action of Trigonella foenum graecum that roles in management of type 2 diabetes mellitus. From many studies, it has been known that Trigonella foenum graecum lowering blood glucose level through several mechanism such as, inhibits the glucose absorbtions in the intestine lumen, lowering the activity of a-amilase enzyme and maltase enzyme, and increase the autofosforilation of insulin in cell surface to improve the glucose uptake on cells. Trigonella foenum graecum also improve the lipid profile through the mechanism such as inhibits the expression of adipogenic genes such as SREBP-1 so that the formation of adipocyte can be stunted, and also inhibits the differentiation of adipocyte from preadipocyte. Fenugreek could be consumed by any kind of form such as fenugreek seeds powder, fenugreek capsule, fenugreek powder mix with food or water, and Fenugreek extract. With 5-25 gram/dayfenugreek can lowering blood glucose level optimally.The use of Trigonella foenum graecum in appropriate dose, in both animals and humans, neither cause a significant toxic side effect, so it is safe to be consumed.
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